Pathogens are faced with a number of physical barriers upon entry in their animal host, whether it be the mucocilliary escalator of the respiratory tract or the acidic environment of the stomach. Following this, they must also overcome innate immune cells expressing pattern recognition receptors that are specialised in identifying and eliminating invading pathogens. During the course of co-evolution, all forms of life have developed sophisticated means by which they can respond to, and fight infection and in turn, pathogens have evolved even more complex mechanisms to subvert these efforts. These mechanisms, such as effector molecules or lifestyle advantages, have always drawn significant attention for their possible exploitation as therapeutic targets. With the rise of antibiotic resistance already at catastrophic levels in some countries, the search for exploitable, novel strategies to target virulence mechanisms is at an all-time high.[...]