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EUROPEAN RESEARCH LABORATORY FOR RHEUMATOID ARTHRITIS – GENHOTEL

European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Ankylosing spondylitis Hybrid modeling Family Health Algeria Europe Antirheumatic Agents Complex genetic disease Shared Epitope ATP Binding Cassette Transporter European Continental Ancestry Group Autoantibodies Adult Rheumatoid Autoimmune thyroid diseases Anti-Idiotypic Biocuration Genetic Non-Receptor Type 22 Animals Analysis Gene Frequency Odds Ratio Metabolic reprogramming Anti-citrullinated protein antibodies Tunisia Genotype Transcriptome Receptors Family POLYMORPHISM Human genomics Arthritis Algerian population Rheumatoid Factor Environment African Continental Ancestry Group Genetic Association Studies France Protein Tyrosine Phosphatase APOPTOSIS Binding Sites Rheumatoid Arthritis Alleles ASSOCIATION STUDY Age Factors Autoantibody Production HLA-DRB1 Reproducibility Case-Control Studies Rheumatoid arthritis Ankylosing Antigens Autoimmunity PTPN22 gene Single Nucleotide Polyarthrite rhumatoïde Male Systems biology Network inference Rare variants ABCB1 Aged RHEUMATOID ARTHRITIS Genetics Young Adult Polymorphism Cohort Studies Logical modelling Age of Onset Génétique Antibodies In silico simulations Autoimmune Diseases HLA-DRB1 Chains Risk Factors Disease maps Epitopes Databases Computational biology 80 and over Computational systems biology Haplotypes Phenotype Biological pathway Biologie computationnelle des systèmes Linkage Disequilibrium Middle Aged Annotation standards Association study Biologie des systèmes Rheumatoid Arthritis Patient Antigen Presentation Adolescent Genetic Predisposition to Disease Humans Computational modeling Genetic Linkage Female HLA-DR Antigens Autoimmune thyroid disease

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